优降宁 盐酸盐
盐酸帕吉林(pargyline hydrochloride)
CAS: 306-07-0
化学式: C11H14ClN
| 中文名 | 盐酸帕吉林 |
| 英文名 | pargyline hydrochloride |
| 别名 | 帕吉林 优降宁 盐酸帕吉林 巴吉林盐酸盐 丙炔甲基苄胺 巴吉林,优降宁 优降宁 盐酸盐 N-甲基-N-丙炔基苄胺 盐酸盐 巴吉林盐酸盐,丙炔甲基苄胺,巴吉林 N-甲基-N-2-丙炔基苄胺 盐酸盐 巴吉林盐酸盐,丙炔甲基苄胺,帕吉林,巴吉林 MAO抑制剂(PARGYLINE HYDROCHLORIDE) |
| 英文别名 | Parguline HCL pargyline hcl PARGYLINE HYDROCHLORIDE pargyline hydrochloride N-benzyl-N-methylprop-2-yn-1-amine benzylmethylpropynylaminehydrochloride n-benzyl-n-methyl-2-propynylaminhydrochloride n-methyl-n-2-propynyl-benzylaminhydrochloride N-METHYL-N-PROPARGYLBENZYLAMINE HYDROCHLORIDE N-Methyl-N-2-propynylbenzylamine hydrochloride N-methyl-N-propargylbenzylamine hydro-chloride n-benzyl-n-methyl-2-propynylaminehydrochloride N-METHYL-N-2-PROPYNYLBENZYLAMINE HYDROCHLORIDE N-METHYL-N-(2-PROPYNY)BENZYLAMINE HYDROCHLORIDE |
| CAS | 306-07-0 |
| EINECS | 206-175-1 |
| 化学式 | C11H14ClN |
| 分子量 | 195.69 |
| InChI | InChI=1/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H |
| InChIKey | BCXCABRDBBWWGY-UHFFFAOYSA-N |
| 熔点 | 160-163°C(lit.) |
| 沸点 | 228.4°C at 760 mmHg |
| 闪点 | 83.9°C |
| 蒸汽压 | 0.0736mmHg at 25°C |
| 存储条件 | -20°C |
| 颜色 | Crystals from EtOH/Et2O |
| Merck | 13,7110 |
| BRN | 3699487 |
| MDL号 | MFCD00012492 |
| 体外研究 | Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner. Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner. Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells. Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression. Cell Proliferation Assay Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM, 1 mM, 1.5 mM or 2 mM Incubation Time: 24 hours, 48 hours, 72 hours, 96 hours or 120 hours Result: Inhibited the proliferation of prostate cancer cells in a time- and dose-dependent manner. Cell Cycle Analysis Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM, 2 mM Incubation Time: 24 hours, 48 hours Result: The S phase ratio of the cells was decreased, while their G1 phase ratio was increased. Apoptosis Analysis Cell Line: LNCaP-LN3 cells Concentration: 0.5 mM Incubation Time: 24 hours Result: Increased the apoptotic cells. Western Blot Analysis Cell Line: LNCaP-LN3 cells Concentration: 2 mM Incubation Time: 48 hours Result: Induced an increase of cytochrome c and a decrease of caspase-3. |
| 体内研究 | Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats. A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DP6650000 |
| FLUKA BRAND F CODES | 10 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 碳酸钠 N-甲基苄胺 盐酸 |
优降宁 盐酸盐 - 介绍
有特异臭。易溶于水。水溶液不稳定，3.18％溶液为等渗溶液。
最后更新：2022-10-16 17:24:28
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提供多种规格现货供应
产品名: N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 去供应商网站查看 询盘CAS: 306-07-0
产地: 北京
包装: 瓶
规格: YS153192-100mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 去供应商网站查看 询盘CAS: 306-07-0
产地: 中国上海
包装: 1g
规格: 97%
价格: 405.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 英文名:Pargyline hydrochloride CAS:306-07-0 规格:97% 产地:中国上 更多
提供多种规格现货供应
产品名: N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 去供应商网站查看 询盘CAS: 306-07-0
产地: 北京
包装: 瓶
规格: YS153192-100mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 去供应商网站查看 询盘CAS: 306-07-0
产地: 中国上海
包装: 1g
规格: 97%
价格: 405.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 英文名:Pargyline hydrochloride CAS:306-07-0 规格:97% 产地:中国上 更多
优降宁 盐酸盐的上游原料
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